Depression and Anxiety Comorbid depression and anxiety disorders occur in up to 25% of general practice patients. About 85% of patients with depression have significant anxiety, and 90% of patients with anxiety disorder have depression. Both the depression disorder and the specific anxiety disorder require appropriate treatment. Psychological therapies, such as cognitive behavior therapy, and antidepressants, occasionally augmented with antipsychotics, have proven benefit for treating both depression and anxiety. Depression and anxiety are the most common psychiatric conditions seen in the general medical setting, affecting millions of individuals in the word. The treatments for depression and anxiety are multiple and have varying degrees of effectiveness. Physical activity has been shown to be associated with decreased symptoms of depression and anxiety. Depression is a multiclausal disorder and has been associated with the risk to develop cancer, dementia, diabetes, epilepsy and s